Anqiu Ning Amprolium Hydrochloride and Ethopabate Premix

[Veterinary Drug Name]

Common Name: Amprolium Hydrochloride and Ethopabate Premix

Product Name: Kerun’an Qiuning

English Name: Amprolium Hydrochloride and Ethopabate Premix

Pinyin: Yansuan'anbinglin Yiyangxian' an Benjiazhi Yuhunji

[Main Ingredients] Amprolium hydrochloride and ethoxyfenamate

【Characteristics】 This product is a off-white powder.

[Pharmacological Actions] Amprolium hydrochloride is effective against all species of coccidia in chickens, with the strongest activity against Eimeria tenella and E. maxima, while its efficacy is weaker against E. necatrix, E. brunetti, E. meleagridis, and E. acervulina. It primarily acts on the first-generation schizonts, inhibiting the formation of merozoites, with peak efficacy occurring on the third day post‑infection. In addition, it also suppresses the sexual reproduction stage and sporozoites. It can be used for both the prevention and treatment of coccidiosis. When combined with sulfamonomethoxine or olaquindox, amprolium hydrochloride broadens its anti‑coccidial spectrum and enhances therapeutic efficacy. Amprolium hydrochloride is also effective against Eimeria species in calves and lambs. This product is a broad‑spectrum anticoccidial agent; its mechanism of action stems from the structural similarity between amprolium and thiamine, which allows it to competitively inhibit the coccidian uptake of thiamine (vitamin B1). ₁ ) is ingested, thereby disrupting carbohydrate metabolism within the parasite’s cells and inhibiting coccidian development.

Ethopabate exhibits synergistic activity against coccidial pathogens such as amprolium and sulfachinoxaline. Its mechanism of action is similar to that of antibacterial potentiators, as it inhibits the synthesis of tetrahydrofolate in coccidia. Ethopabate demonstrates potent efficacy against Eimeria maxima, E. bovis, and other small‑intestine coccidia, thereby addressing the limited effectiveness of amprolium against these species. Conversely, ethopabate’s lack of activity against Eimeria tenella can be offset by amprolium’s characteristic spectrum of action. This explains why ethopabate is typically used in combination with amprolium rather than as a standalone agent. The peak period of its activity occurs on the fourth day of the coccidian life cycle following infection.

[Drug Interactions] Due to amprolium and vitamin B ₁ It can exert competitive antagonistic effects. If the concentration in mixed feed is too high, it may cause vitamin B deficiency in chicks. ₁ Deficiency. When the vitamin B in the feed… ₁ When the concentration exceeds 10 mg/kg, its anticoccidial efficacy is reduced.

[Functions and Uses] An anticoccidial drug. Used for coccidiosis in chickens.

【Usage and Dosage】 Based on this product. Mixed feeding: 500 g per 1,000 kg of feed for chickens.

[Adverse Reactions] No adverse reactions have been observed when used as directed.

[Precautions]

(1) May be used in commercial feed and during the farming process.

(2) Chickens raised for egg production intended for human consumption shall not be used during the laying period.

[Withdrawal Period] Chicken, 72 hours.

[Specification] 1000 g: Amprolium hydrochloride 250 g + Ethopabate 16 g

[Packaging] 25 kg/bag

[Storage] Protect from light, keep sealed, and store in a dry place.

[Expiration Date] 2 years.

[Approval Number] Veterinary Drug No. 191321369

[Manufacturing Enterprise] Guangdong Kerun Biopharmaceutical Co., Ltd.

• 盐酸
• 作用
• 酰胺
• b1
• 维生素
• 本品
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• 机理
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