Taimiaojing Tiamulin Fumarate Premix

[Veterinary Drug Name]

Common Name: Tiamulin Fumarate Premix

Product Name: Keruntai Miaojing

English Name: Taimulin Fumarate Premix

Pinyin: Yanhusuosuan Taimiaojunsu Yuhunji

[Main Ingredients] Tiamulin Fumarate

【Characteristics】 This product is a off-white granule or powder.

[Pharmacological Actions]

Pharmacodynamics Tiamulin is a pleuromutilin antibiotic that exhibits bactericidal activity against susceptible bacteria at high concentrations. It inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit.

Tiamulin exhibits potent antibacterial activity against Mycoplasma and Brachyspira hyodysenteriae, and also demonstrates good activity against most Gram-positive bacteria, including staphylococci and streptococci (except for Group D streptococci). It shows some efficacy against Actinobacillus pleuropneumoniae, but its antibacterial activity against most Gram-negative bacteria is relatively weak.

When combined with chlortetracycline at a ratio of 1:4, this product is effective in treating bacterial enteritis, bacterial pneumonia, and swine dysentery caused by Brachyspira in pigs. It also demonstrates significant therapeutic efficacy against pneumonia resulting from mixed infections involving Mycoplasma pneumoniae, Bordetella bronchiseptica, and Pasteurella multocida.

Pharmacokinetics Oral administration of tylvalosin in pigs is well absorbed. Following a single dose, bioavailability is approximately 85%, with peak plasma concentrations reached within 2 to 4 hours. The drug is widely distributed throughout the body, with the highest concentrations found in lung tissue. Tylvalosin undergoes extensive metabolism in vivo, yielding more than 20 metabolites, some of which exhibit antibacterial activity. Metabolites of tylvalosin are primarily excreted in the feces via bile, with about 30% eliminated in the urine.

[Drug Interactions]

(1) Concurrent use with polyether antibiotics such as monensin, salinomycin, and methylsalinomycin may alter the metabolism of these polyether antibiotics, leading to stunted growth, ataxia, paralysis, and even death.

(2) When used in combination with other antibiotics that bind to the 50S subunit of bacterial ribosomes, such as macrolides and lincomycin, competitive binding at the same site may result in reduced therapeutic efficacy.

[Functions and Uses] A truncated pleuromutilin antibiotic. It is primarily used for the prevention and treatment of porcine mycoplasmal pneumonia and Actinobacillus pleuropneumonia, and is also indicated for swine dysentery caused by Brachyspira.

【Usage and Dosage】 Based on this product. Mixed into feed: 50–125 g per 1,000 kg of feed for pigs, administered continuously for 5–10 days.

[Adverse Reactions] When used at the recommended dose, pigs may occasionally develop skin erythema. Overdose may cause transient salivation, vomiting, and central nervous system depression in pigs.

[Precautions]

(1) Concurrent use with polyether antibiotics such as monensin, salinomycin, and methylsalinomycin is prohibited.

(2) Users should avoid contact between the medication and the eyes or skin.

[Withdrawal Period] Pig, 7 days.

[Specification] 80%

[Packaging] 100 g/bag; 500 g/bag.

[Storage] Protect from light, keep tightly sealed, and store in a dry place.

[Expiration Date] 2 years

[Approval Number] Veterinary Drug No. 191323010

[Manufacturing Enterprise] Guangdong Kerun Biopharmaceutical Co., Ltd.

• 延胡索
• 类抗生素
• 菌素
• 肺炎
• 抗菌
• 霉素
• 活性
• 引起
• 痢疾
• 本品